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No specific dose adjustment encouraged when tofacitinib coadministered with powerful CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both equally reasonable CYP3A4 and potent CYP2C19 inhibitors .cyclophosphamide will increase the amount or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Impor